Book Table of Contents

Contents

About the Author .................................................................. xii

Dedication ............................................................................. xiii

Preface to 1st & 2nd Editions and Acknowledgements xiv

Preface to 3rd Edition (Book Description) .................... xix

INTRODUCTION

Children With Real Medical Illnesses ............ 1

A Message of Hope ............................................................... 1

Defeat Autism Now! .............................................................. 3

What Can a Parent Expect From Biomedical Interventions? .. 6

My Personal and Professional Involvement
in the Bio-Medicine of Autism ........................................... 8

My Most Challenging Case .................................................. 10

ONE

Causation Models ........................................... 15

The Worldwide Autism Spectrum Disorder (ASD) Epidemic . 15

Definition of ASD and Incidence of Classic vs. Regressive Autism 16

What Causes Autism and Other ASDs? ................................ 17

Simply Genetic? ........................................................... 18

The Toxic Chemical Model ............................................ 19

The Heavy Metal Contamination Model ........................... 20

Vaccinations ................................................................. 21

The Auto-immunity/Allergy Model ................................... 24

The Viral Model ............................................................ 26

The Gluten/Casein, Enzyme Deficiency
and Yeast Overgrowth Model .................................... 27

The Metallothionein Theory ............................................ 29

How Models of Causation Lead to Treatments That Work ..... 30

TWO

Gastrointestinal Pathology—
Nutritional Deficiencies ................................. 35

Nutritional Deficiency as a Common Denominator ............... 35

Causes of Gastrointestinal Problems in ASD Children ......... 38

How the Immune and GI Systems Interact ........................... 39

How Yeast Overgrowth Can Injure the Gastrointestinal System 41

“Leaky Gut”, Increased Permeability of the Intestinal Mucosa
and Malabsorption .................................................... 42

Further Notes on the Mercury/Vaccine Connection ......... 44

Putting the Puzzle Pieces Together .................................... 44

THREE

Impaired Detoxification, Toxic Accumulations,
and Politics ....................................................... 48

Toxic Threats to Child Development .................................... 48

The Mechanism of Heavy Metal Toxicity .............................. 51

Specific Heavy Metals: Lead and Mercury ............................ 52

Lead ............................................................................ 52

Mercury ........................................................................ 53

Mercury in Vaccines ............................................................ 54

The Saga of Several Autism Parents and “Parent Power” .... 56

FOUR

Clinical and Diagnostic Evaluation ............. 60

Biomedical Evaluation ........................................................ 60

Family and Medical History ........................................... 61

Pre-testing Considerations ............................................ 63

New Diagnostics in ASD Based on Screening ...................... 64

Initial Strategies in Test Evaluation ..................................... 65

More Tests, New Philosophy ......................................... 65

Parents, Doctors, and Testing Philosophy ..................... 66

Descriptions of Specific Laboratory Tests ............................ 69

Necessary Preliminary Screening Tests .......................... 69

Complete Blood Count (CBC) with Differential
and Platelets .................................................... 69

Comprehensive Metabolic Panel ............................ 69

Thyroid Panel ...................................................... 69

Urinalysis ............................................................. 69

Hair Analysis (Part of Heavy Metal Screening) ........ 69

Specialized Laboratory Tests as Individually Indicated ........ 71

Urinary Peptide Tests for Casein and Gluten ................... 72

Organic Acid Test (OAT–urine) ...................................... 73

90-Food IgG Antibodies Test (Serum) ........................... 73

Amino Acids (Plasma) ................................................... 74

Comprehensive Microbial Digestive Stool Analysis ......... 75

Fatty Acid Analysis (Plasma) ......................................... 75

Tests for Metallothionein Dysfunction ........................... 76

Laboratory Testing in Chelation Therapy ............................. 76

Immunology Testing ........................................................... 77

Which Laboratories to Use ................................................... 77

FIVE

Gastrointestinal Healing ................................ 80

Gastrointestinal Health is a Key Issue ................................. 80

Treatments That Can Be Implemented by Parents ................ 83

The GF/CF/SF (Gluten, Casein, Soy Free) Diet ............... 83

How to Start the Diet ............................................. 85

Where to Get Help ................................................ 86

Enzymes ...................................................................... 90

Probiotics .................................................................... 92

Basic Nutrient Supplementation ..................................... 93

Gastrointestinal Treatments That Require Physician Participation 95

Anti-fungal Treatment .................................................... 96

Other Gut Pathogens and Treatments ............................. 99

The Secretin Story ............................................................. 100

Summary–Gut Health and Healing ..................................... 105

SIX

Feeding the Starving Brain ......................... 109

Vital Nutrients ................................................................... 109

Nutritional Deficiencies Identified in Our Children .......... 111

The Use of Vital Nutrients ............................................ 112

Primary Recommended Supplements ........................... 114

The Rationale Behind the Use of Specific Nutrients ............ 119

B6 and Magnesium ..................................................... 119

Zinc ............................................................................ 120

Calcium ...................................................................... 121

Selenium .................................................................... 121

Vitamin A and High-Dose Vitamin A Protocol ............... 121

Vitamins C and E ........................................................ 122

Essential Fatty Acids .................................................. 123

DMG and TMG ............................................................ 124

B-Vitamins .................................................................. 125

Amino Acids ............................................................... 127

Additional Minerals ...................................................... 127

Nutrient Interactions .......................................................... 128

Testing for Nutritional Deficiencies .................................... 128

Parents Say Nutrients Help Their Children ......................... 129

SEVEN

Removing the Heavy Metals ...................... 133

Heavy Metal Toxicity .......................................................... 133

A Practical Approach to the Removal of Mercury ............... 135

Pre-Chelation Testing ....................................................... 139

Hair Analysis .............................................................. 139

Porphyrin Testing ........................................................ 140

Pre- and Post-Challenge Urine Toxic Elements Test ...... 141

RBC Essential Elements .............................................. 142

Cysteine ..................................................................... 142

Gut Readiness Before Starting Chelation ........................... 142

Organic Acid Test (OAT) .............................................. 143

Comprehensive Microbial Digestive Stool Analysis ....... 143

Nutrient/Mineralization Readiness ...................................... 144

Heavy Metal Detoxification per 2005 Defeat Autism Now! Consensus, Summary 145

Phase I, DMSA (Di-mercaptosuccinic Acid)
Dosages and Timing ............................................... 147

Dosages, DMSA ......................................................... 147

Lab Monitoring ............................................................ 148

Readiness for Second Phase: Adding A-lipoic Acid (ALA) 148

Second Phase, Laboratory Monitoring ......................... 149

Completion of Chelation Process ................................. 150

Alternative Detoxification Treatment ................................... 152

Allithiamine: Transdermal Thiamine Tetrahydrofurfuryl
Disulfide (TTFD) ...................................................... 152

Summary .................................................................... 157

General Comments on Detoxification Treatment ................ 158

EIGHT

Immunity, Autoimmunity and Viruses ....... 164

An Overview of Immune Dysregulation in ASD Children .... 164

Genetics ..................................................................... 164

Immune Abnormalities ................................................. 165

Autoimmunity and Autism ............................................ 166

Pathogens and Autoimmunity ...................................... 166

Gastrointestinal Disease and Autism Spectrum Disorder 167

MMR and Developmental Regression ................... 167

Fungal Infections and the Immune System ............ 167

Atypical Elevations of Common Viral Titers .................. 168

Allergy and Immunity ................................................... 168

Chronic Low-grade Infections ....................................... 169

Diagnostics–Immune Testing ............................................. 169

Comprehensive (Herpes) Viral Screen ........................... 170

Myelin Basic Protein (MBP) Antibodies ........................ 170

Case History—Suzie .......................................................... 170

Anti-Viral and Immune Treatment Issues ........................... 173

Treatments to Enhance the Immune System .................. 175

Immunomodulators and Immune Boosters ............ 175

Natural Immunomodulators ........................... 176

Probiotics as Immunomodulators ......................... 178

Glutathione, or GSH ............................................ 179

IVIG (Intravenous Immune Globulin [Human]) ................. 180

High-Dose Vitamin A Protocol ..................................... 180

Prescription Immune-Enhancing Medications ................ 181

Anti-viral Prescription Medications ............................... 181

A Parent’s Story—Stan Kurtz ............................................. 182

Viral/Immune Treatment Summary ................................... 184

NINE

HBOT- Hyperbaric Oxygen Therapy
for autism spectrum disorders ... 190

Written by James Neubrander, MD,
Reviewed and edited by Dan Rossignol, MD

Foreword ........................................................................... 191

History and Description ..................................................... 191

Benefits ............................................................................. 192

Side Effects ....................................................................... 195

Multiple Mechanisms of Action .......................................... 197

Basic Principles and Safe Protocols .................................. 198

Questions and Concerns .................................................... 199

Summary ........................................................................... 203

Selected Bibliography ........................................................ 203

TEN

Latest Developments ................................... 205

A . Methylation, with Richard Deth, PhD,
Jaquelyn McCandless, MD ............................................. 206

B . Genetic Testing for Methylation Defects, Cynthia Schneider, MD 216

C . Actos, Michael Elice, MD ............................................... 222

D . Low-Dose Naltrexone, Jaquelyn McCandless, MD ......... 227

E . Low Oxalate Diet, Susan Owens ..................................... 236

ELEVEN

Mitochondrial Dysfunction & Treatments . 247

A. Introduction ................................................................... 247

B. Treatment Issues ........................................................... 252

1. Drugs and Medical States That Negatively Affect
Mitochondria ........................................................... 252

2. Testing for Mitochondrial Dysfunction ...................... 253

3. Current Mainstream Medical Treatment Strategies for Mitochondrial Disorder 254

4. Mitochondrially Targeted Nutrients to Treat ASD ....... 255

Important Nutrients for Supporting Mitochondrial Health ... 257

TWELVE

Starving Brains, Starving Hearts,
What Does It All Mean? ........................................ 268

Jack Zimmerman, PhD

Messages ........................................................................... 268

Jaquelyn, Chelsey and Elizabeth ....................................... 271

Awareness of Subtle Relationships .................................... 282

Final Words ....................................................................... 284

APPENDICES

Appendix A:
Progress in Gastrointestinal Research and Its Relationship to
Immunity in Autism
By Teresa Binstock ........................................................ 286

Appendix B:
Autism, Metals, and the Mercury in Vaccines,
and the alternative version of the
“Autism/Mercury Paper”
by Sallie Bernard, Albert Enayati, Heidi Roger,
Lyn Redwood, Teresa Binstock.
Introductory Comments by Teresa Binstock .................. 293

Appendix C:
Intra-Body Toxins
by Teresa Binstock ....................................................... 320

Appendix D:
Mitochondrial Concerns
by Teresa Binstock ........................................................ 330

Appendix E:
Implications for Medicine, Education and
the Environment
by Jack Zimmerman, PhD .............................................. 343

A Poetic Version of our
Journey with Chelsey ......................... 362

Index .............................................................. 383


	Contents About the Author .................................................................. xii Dedication ............................................................................. xiii Preface to 1st & 2nd Editions and Acknowledgements xiv Preface to 3rd Edition (Book Description) .................... xix INTRODUCTION Children With Real Medical Illnesses ............ 1 A Message of Hope ............................................................... 1 Defeat Autism Now! .............................................................. 3 What Can a Parent Expect From Biomedical Interventions? .. 6 My Personal and Professional Involvement in the Bio-Medicine of Autism ........................................... 8 My Most Challenging Case .................................................. 10 ONE Causation Models ........................................... 15 The Worldwide Autism Spectrum Disorder (ASD) Epidemic . 15 Definition of ASD and Incidence of Classic vs. Regressive Autism 16 What Causes Autism and Other ASDs? ................................ 17 Simply Genetic? ........................................................... 18 The Toxic Chemical Model ............................................ 19 The Heavy Metal Contamination Model ........................... 20 Vaccinations ................................................................. 21 The Auto-immunity/Allergy Model ................................... 24 The Viral Model ............................................................ 26 The Gluten/Casein, Enzyme Deficiency and Yeast Overgrowth Model .................................... 27 The Metallothionein Theory ............................................ 29 How Models of Causation Lead to Treatments That Work ..... 30 TWO Gastrointestinal Pathology— Nutritional Deficiencies ................................. 35 Nutritional Deficiency as a Common Denominator ............... 35 Causes of Gastrointestinal Problems in ASD Children ......... 38 How the Immune and GI Systems Interact ........................... 39 How Yeast Overgrowth Can Injure the Gastrointestinal System 41 “Leaky Gut”, Increased Permeability of the Intestinal Mucosa and Malabsorption .................................................... 42 Further Notes on the Mercury/Vaccine Connection ......... 44 Putting the Puzzle Pieces Together .................................... 44 THREE Impaired Detoxification, Toxic Accumulations, and Politics ....................................................... 48 Toxic Threats to Child Development .................................... 48 The Mechanism of Heavy Metal Toxicity .............................. 51 Specific Heavy Metals: Lead and Mercury ............................ 52 Lead ............................................................................ 52 Mercury ........................................................................ 53 Mercury in Vaccines ............................................................ 54 The Saga of Several Autism Parents and “Parent Power” .... 56 FOUR Clinical and Diagnostic Evaluation ............. 60 Biomedical Evaluation ........................................................ 60 Family and Medical History ........................................... 61 Pre-testing Considerations ............................................ 63 New Diagnostics in ASD Based on Screening ...................... 64 Initial Strategies in Test Evaluation ..................................... 65 More Tests, New Philosophy ......................................... 65 Parents, Doctors, and Testing Philosophy ..................... 66 Descriptions of Specific Laboratory Tests ............................ 69 Necessary Preliminary Screening Tests .......................... 69 Complete Blood Count (CBC) with Differential and Platelets .................................................... 69 Comprehensive Metabolic Panel ............................ 69 Thyroid Panel ...................................................... 69 Urinalysis ............................................................. 69 Hair Analysis (Part of Heavy Metal Screening) ........ 69 Specialized Laboratory Tests as Individually Indicated ........ 71 Urinary Peptide Tests for Casein and Gluten ................... 72 Organic Acid Test (OAT–urine) ...................................... 73 90-Food IgG Antibodies Test (Serum) ........................... 73 Amino Acids (Plasma) ................................................... 74 Comprehensive Microbial Digestive Stool Analysis ......... 75 Fatty Acid Analysis (Plasma) ......................................... 75 Tests for Metallothionein Dysfunction ........................... 76 Laboratory Testing in Chelation Therapy ............................. 76 Immunology Testing ........................................................... 77 Which Laboratories to Use ................................................... 77 FIVE Gastrointestinal Healing ................................ 80 Gastrointestinal Health is a Key Issue ................................. 80 Treatments That Can Be Implemented by Parents ................ 83 The GF/CF/SF (Gluten, Casein, Soy Free) Diet ............... 83 How to Start the Diet ............................................. 85 Where to Get Help ................................................ 86 Enzymes ...................................................................... 90 Probiotics .................................................................... 92 Basic Nutrient Supplementation ..................................... 93 Gastrointestinal Treatments That Require Physician Participation 95 Anti-fungal Treatment .................................................... 96 Other Gut Pathogens and Treatments ............................. 99 The Secretin Story ............................................................. 100 Summary–Gut Health and Healing ..................................... 105 SIX Feeding the Starving Brain ......................... 109 Vital Nutrients ................................................................... 109 Nutritional Deficiencies Identified in Our Children .......... 111 The Use of Vital Nutrients ............................................ 112 Primary Recommended Supplements ........................... 114 The Rationale Behind the Use of Specific Nutrients ............ 119 B6 and Magnesium ..................................................... 119 Zinc ............................................................................ 120 Calcium ...................................................................... 121 Selenium .................................................................... 121 Vitamin A and High-Dose Vitamin A Protocol ............... 121 Vitamins C and E ........................................................ 122 Essential Fatty Acids .................................................. 123 DMG and TMG ............................................................ 124 B-Vitamins .................................................................. 125 Amino Acids ............................................................... 127 Additional Minerals ...................................................... 127 Nutrient Interactions .......................................................... 128 Testing for Nutritional Deficiencies .................................... 128 Parents Say Nutrients Help Their Children ......................... 129 SEVEN Removing the Heavy Metals ...................... 133 Heavy Metal Toxicity .......................................................... 133 A Practical Approach to the Removal of Mercury ............... 135 Pre-Chelation Testing ....................................................... 139 Hair Analysis .............................................................. 139 Porphyrin Testing ........................................................ 140 Pre- and Post-Challenge Urine Toxic Elements Test ...... 141 RBC Essential Elements .............................................. 142 Cysteine ..................................................................... 142 Gut Readiness Before Starting Chelation ........................... 142 Organic Acid Test (OAT) .............................................. 143 Comprehensive Microbial Digestive Stool Analysis ....... 143 Nutrient/Mineralization Readiness ...................................... 144 Heavy Metal Detoxification per 2005 Defeat Autism Now! Consensus, Summary 145 Phase I, DMSA (Di-mercaptosuccinic Acid) Dosages and Timing ............................................... 147 Dosages, DMSA ......................................................... 147 Lab Monitoring ............................................................ 148 Readiness for Second Phase: Adding A-lipoic Acid (ALA) 148 Second Phase, Laboratory Monitoring ......................... 149 Completion of Chelation Process ................................. 150 Alternative Detoxification Treatment ................................... 152 Allithiamine: Transdermal Thiamine Tetrahydrofurfuryl Disulfide (TTFD) ...................................................... 152 Summary .................................................................... 157 General Comments on Detoxification Treatment ................ 158 EIGHT Immunity, Autoimmunity and Viruses ....... 164 An Overview of Immune Dysregulation in ASD Children .... 164 Genetics ..................................................................... 164 Immune Abnormalities ................................................. 165 Autoimmunity and Autism ............................................ 166 Pathogens and Autoimmunity ...................................... 166 Gastrointestinal Disease and Autism Spectrum Disorder 167 MMR and Developmental Regression ................... 167 Fungal Infections and the Immune System ............ 167 Atypical Elevations of Common Viral Titers .................. 168 Allergy and Immunity ................................................... 168 Chronic Low-grade Infections ....................................... 169 Diagnostics–Immune Testing ............................................. 169 Comprehensive (Herpes) Viral Screen ........................... 170 Myelin Basic Protein (MBP) Antibodies ........................ 170 Case History—Suzie .......................................................... 170 Anti-Viral and Immune Treatment Issues ........................... 173 Treatments to Enhance the Immune System .................. 175 Immunomodulators and Immune Boosters ............ 175 Natural Immunomodulators ........................... 176 Probiotics as Immunomodulators ......................... 178 Glutathione, or GSH ............................................ 179 IVIG (Intravenous Immune Globulin [Human]) ................. 180 High-Dose Vitamin A Protocol ..................................... 180 Prescription Immune-Enhancing Medications ................ 181 Anti-viral Prescription Medications ............................... 181 A Parent’s Story—Stan Kurtz ............................................. 182 Viral/Immune Treatment Summary ................................... 184 NINE HBOT- Hyperbaric Oxygen Therapy for autism spectrum disorders ... 190 Written by James Neubrander, MD, Reviewed and edited by Dan Rossignol, MD Foreword ........................................................................... 191 History and Description ..................................................... 191 Benefits ............................................................................. 192 Side Effects ....................................................................... 195 Multiple Mechanisms of Action .......................................... 197 Basic Principles and Safe Protocols .................................. 198 Questions and Concerns .................................................... 199 Summary ........................................................................... 203 Selected Bibliography ........................................................ 203 TEN Latest Developments ................................... 205 A . Methylation, with Richard Deth, PhD, Jaquelyn McCandless, MD ............................................. 206 B . Genetic Testing for Methylation Defects, Cynthia Schneider, MD 216 C . Actos, Michael Elice, MD ............................................... 222 D . Low-Dose Naltrexone, Jaquelyn McCandless, MD ......... 227 E . Low Oxalate Diet, Susan Owens ..................................... 236 ELEVEN Mitochondrial Dysfunction & Treatments . 247 A. Introduction ................................................................... 247 B. Treatment Issues ........................................................... 252 1. Drugs and Medical States That Negatively Affect Mitochondria ........................................................... 252 2. Testing for Mitochondrial Dysfunction ...................... 253 3. Current Mainstream Medical Treatment Strategies for Mitochondrial Disorder 254 4. Mitochondrially Targeted Nutrients to Treat ASD ....... 255 Important Nutrients for Supporting Mitochondrial Health ... 257 TWELVE Starving Brains, Starving Hearts, What Does It All Mean? ........................................ 268 Jack Zimmerman, PhD Messages ........................................................................... 268 Jaquelyn, Chelsey and Elizabeth ....................................... 271 Awareness of Subtle Relationships .................................... 282 Final Words ....................................................................... 284 APPENDICES Appendix A: Progress in Gastrointestinal Research and Its Relationship to Immunity in Autism By Teresa Binstock ........................................................ 286 Appendix B: Autism, Metals, and the Mercury in Vaccines, and the alternative version of the “Autism/Mercury Paper” by Sallie Bernard, Albert Enayati, Heidi Roger, Lyn Redwood, Teresa Binstock. Introductory Comments by Teresa Binstock .................. 293 Appendix C: Intra-Body Toxins by Teresa Binstock ....................................................... 320 Appendix D: Mitochondrial Concerns by Teresa Binstock ........................................................ 330 Appendix E: Implications for Medicine, Education and the Environment by Jack Zimmerman, PhD .............................................. 343 A Poetic Version of our Journey with Chelsey ......................... 362 Index .............................................................. 383